 The relationship between humans and bacteria has long been complex, with both beneficial and harmful effects on each other's lives. Pathogenic bacteria can cause serious illnesses while probiotics, such as intestinal flora, can help maintain good health. To better understand how these microorganisms interact, researchers have developed laminogens with aggregation-induced emission, Ae, properties, which are highly sensitive fluorescent agents used for imaging microorganisms. These Ae-gens have shown promise in detecting and differentiating between gram-negative and gram-positive bacteria, as well as imaging intracellular bacteria and fungi. They can also be used to monitor bacteria, sell interactions, and even to engineer bacteria, Ae-gen hybrids for cancer therapy. This article was authored by Zyu-A-Yi, Wei-Hee, Zitsong Zhang, and others.