 Neem and Pixi disease is a rare inherited disorder characterized by the build-up of cholesterol and other fats in cells. It can cause a range of symptoms including neurological issues such as vertically super nuclear gaze palsy, dysarthria, dysphagia, and progressive dementia. There are two types of mutation in the NPC1 and NPC2 genes which lead to the disease. Diagnosis is confirmed through a biopsy of skin fibroblasts which show accumulations of unesterified cholesterol in perinuclear vesicles. Treatments are available for some symptoms, but there is no cure for the condition. This article was authored by Vonia Marie T.