 In this study, we applied the reduced-reverse degree-based indices introduced in 2021 by Vignesh et al. to predict the physical chemical properties of a family of benzenoid hydrocarbon molecules. Our results showed that these indices were able to accurately predict the physical and chemical properties of the molecules. Furthermore, we compared the predictive capabilities of the reduced-reverse degree-based indices against 16 existing degree-based indices. Finally, we computed the defined reduced-reverse degree-based topological indices for hyaluronic acid-pacletaxyl conjugates 505733HAP, underscore N505733HAP, N505733N backslash GE1505733N greater than or equal to 1. This article was authored by Vignesh Ravi and Kalyani Desikan.