 The review aims to identify regulatory frameworks and policies governing clinical trial data sharing, explore key elements of data sharing mechanisms as outlined in existing regulatory documents, and suggest focal areas for policy interventions on a systematic basis to facilitate clinical trial data sharing. The results show that most clinical trial agencies mandate a data sharing agreement, require informed consent by trial participants, and outline requirements for a data sharing proposal review committee. Data sharing policies have milestone-based timelines when clinical trial data can be shared, and the review classifies clinical trial agencies as either controlled or open access data sharing models. The review recommends developing a pragmatic data sharing mechanism to improve research and innovations, facilitate cross-border collaborations, augment participant privacy and confidentiality, and guide data generation, which is the foundation of all scientific endeavor. This article was authored by Nachiket Goody, Prashanthi Kamath, Trishneka Chakraborty, and others.