 Infections mediated by broad host range entomopathogenic fungi represent seminal observations that led to one of the first germ theories of disease and are a classic example of a co-evolutionary arms race between a pathogen and target hosts. Insects have evolved a number of mechanisms to keep pathogens at bay that include the production of AP, cuticular antimicrobial lipids, proteins, and metabolites. This article was authored by Nimat Okihani and Almydina Ortizarquisa.