 Purpose-Weaker Wolf syndrome is a rare genetic condition caused by mutations in the ZC4H2 gene. Symptoms include arthrogroposis multiplex congenita, AMC, intellectual disability, ID, and impaired central and peripheral synaptic plasticity. This study reports on six cases of the syndrome and provides insight into its very clinical manifestations. This article was authored by Jiyeon, Suyeon Kim, Byungchan Lim, and others.