 This study examined the prevalence and severity of quality of life, QOL, related health problems, and sub-Saharan Africa, SSA. It was found that there are inconsistencies in how these problems have been researched and reported across studies, making it difficult to compare findings and draw conclusions. Factors such as demographic characteristics, age and marital status, cancer related factors, stage and type of treatment, and social determinants of health, access to information and resources, financial distress, and urban versus rural residency, all impacted QOL and its sub-domains. This study indicates the significant need for recognizing and managing QOL related problems for cancer patients and caregivers in SSA. Additionally, comprehensive supportive care is necessary to address the complex QOL issues in resource limited SSA. This article was authored by Yusef Kanner, Ting Guan, Eno Idiadbonia, and others.