 This study shows that indoor residual spraying, IRS, with non-pyrethroid insecticides, combined with long-lasting insecticidal nets, lins, can significantly reduce the reservoir of plasmonium felsiparum infections in high-burden countries in sub-Saharan Africa. The study also suggests that molecular surveillance should be used to monitor progress towards pre-elimination. This article was authored by Katharine Teege, Abraham Oroduro, Oscar Banger, and others.