 Cellular senescence is a state of irreversible replicative arrest and apoptosis resistance that leads to tissue destruction through a pro-inflammatory secretory phenotype, SASP. Senescent cells accumulate with aging and contribute to various age-related diseases. Discovering pro-survival senescent cell anti-apoptotic pathways, SCAPs, has led to the development of senolytic agents, drugs that eliminate senescent cells, which are showing promise in pre-clinical models and are being translated into clinical interventions. This article was authored by James L. Kirkland and Tamara Tkonia.