 The nucleocapsid protein, N, of SARS-CoV-2 plays a crucial role in the viral life cycle. It is responsible for packaging the large genome into virus particles, as well as regulating the expression of genes. Additionally, it has been shown to recognize specific RNA motifs, which are important for viral replication. Using nuclear magnetic resonance spectroscopy, researchers have identified the binding preferences of NS and terminal RNA binding domain, NTD, with these motifs. This study provides insight into how N recognizes and binds to specific RNA motifs, allowing for more efficient viral replication. This article was authored by Sophie Marianne Corn, Kavikei and Damatharan, Siam Jeffries, and others.