 Flexible surface-enhanced Raman scattering CRS spectroscopy is a highly sensitive and non-invasive technique for detecting a wide range of molecules with recent research focusing on its unique advantages compared to rigid substrate-based SCRS. The report highlights the latest advances in flexible SCRS diagnostic devices, including point-of-care diagnostics, cutting-edge SCRS techniques, actively-tunable SCRS, swab sampling strategy, and in situ SCRS detection approach. These flexible SCRS substrates with low cost, batch fabrication, and easy-to-operate characteristics can be integrated into portable Raman spectroscopes for point-of-care diagnostics, which are conceivable to penetrate global markets and households as next-generation wearable sensors in the near future.