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Published on Mar 18, 2012
In the rapidly evolving field of microRNA research, which still relies heavily on a variety of measurement techniques and prediction algorithms for target identification, the challenge is in identifying the most biologically relevant targets. To identify potential microRNA markers for disease progression from primary melanoma to metastatic melanoma, Ingenuity scientists applied biological information to prioritize mRNA targets, understand how these biomarker candidates contribute to disease progression, and design followup experiments to test their hypotheses. IPA®'s new microRNA Target Filter functionality enables prioritization of experimentally validated and predicted mRNA targets through the addition of biological information from the Ingenuity Knowledge Base and the ability to include experimental results in a single application.