 Corcidin, QUE, a flavonoid with powerful antioxidant properties, has gained much interest from the scientific community due to its potential health benefits. However, its poor solubility and extensive first-pass metabolism limits its oral administration. Nanoformulations, such as lipid-based nano-carriers, polymer-based nano-carriers, and cyclo-dextrons, can be used to overcome these limitations and improve QUE bioavailability. Liposomes, nanostructured lipids, and solid lipid nanoparticles are commonly used to increase QUE absorption and targeting, while polymer-based nano-carriers can reduce QUE's ADME, T, profile. Additionally, neosomes, nano-emulsions, and cyclo-dextrons can be used to deliver QUE through different routes. Overall, this review provides an overview of the potential of advanced drug-delivery nano-systems for the formulation and delivery of QUE. This article was authored by Ekaterina Makayla Tomu, Paraskevi Papakaryakapalu, Elmina Marina Saitani, and others. We are article.tv, links in the description below.