 Acetaminophen, APAP, is a commonly used pain reliever and fever reducer that has been linked to liver damage when taken in excessive amounts. The exact mechanism behind this liver damage is still unclear, but it is believed to involve oxidative stress caused by the breakdown of APAP into toxic compounds. Studies have shown that mitochondria are the primary source of these toxic compounds, suggesting that mitochondria-targeted antioxidant therapies effective in treating APAP-induced liver damage. Additionally, recent research has demonstrated that immune cells do not play a significant role in APAP-induced liver damage, suggesting that mitochondria-targeted antioxidant therapy could be a viable treatment option for patients who have ingested large doses of APAP. This article was authored by Kudu, Anupramachandran, and Hartmut Jaishki.