 Macrophages are important immune cells that play a key role in the foreign body reaction following biomaterial implantation. They are able to recognize and engulf foreign material, as well as initiate the inflammatory process. Physical chemical cues on the biomaterial surface can influence macrophage behavior, leading to either positive or negative outcomes depending on the type of interaction. Understanding how these cues affect macrophage behavior can help us develop new biomaterials that elicit a favorable immune response upon implantation. This article was authored by Zishan Sheikh, Patricia J. Brooks, Oriah Barzale and others.