 Entrohemorrhagic E. coli, EHEC, is a pathogenic strain of Escherichia coli that can cause severe illnesses such as bloody diarrhea and kidney failure when ingested through contaminated food or water. The bacteria produce Shiga toxins, STX, which are released into the gut lumen after bacterial lysis. It is unclear how these toxins cross the intestinal epithelial barrier and gain access to the bloodstream. Current research suggests that the intestinal environment plays a key role in STX production and release, as well as their interaction with intestinal epithelial cells and subsequent uptake into underlying tissues. Further research is needed to better understand this process and its implications for human health. This article was authored by Stephanie Schuller.