 Okay, second thanks everyone to come here for this one for you many First also, I would like also thanks a brand foundation and all the donors and the sponsors It's really my great honor to receive this generous award We work on a brand blood vessel disease called the brand arterial venous male formation also called AVM In AVMs the artery connect with one directly without capillary between them So the high pressure blood from artery inject into the one directly without any buffer So since the wall of the one is seen and weak, so this post a high risk of bleeding, which is a stroke and AVM affect many children and young adult And each year in Australia only the cause hundreds of deaths or serious disabilities current treatment are Removing the abnormal vessel by surgical procedures or blocks the blood flow by injecting special glue inside the vessels Or by radio surgery These procedures eliminates the risk of bleeding however each of the procedure has limitations and that no effective treatment Is available for many AVM patients We are working to develop a effective biological treatment to treat this disease We will use radiation to selectively make markers on the AVM vessel and Then use specially designed medicine we call it to recognize these markers and band to them So special medicine then clots the blood in the vessel and the cloud will block the blood flow and Eliminate the risk of bleeding We will use this award to identify the markers induced by radiation on AVM vessels This is a key step in developing this technique We will then design the special medicine and test them in animals and clinical trials Successful development of this technique will provide an effective treatment for AVM patients and Save the life for these young people. Thank you very much