 Functional limitation in Buruliosa disease is quite a common complication. It may occur before a diagnosis of Buruliosa is made or after lesions have healed spontaneously or with antibiotic treatment. These functional limitations range from scarring to flexion deformities and to amputations. Regarding flexion deformities, these patients must be managed with continuous and immediate physiotherapy. In practical terms, patients should be encouraged to use the affected limb as often as can be tolerated. When these flexion deformities are extensive and severe, the inputs of a physiotherapist and or a plastic surgeon may be required.