 This study found that oral administration of a hot water extract of curcuma longer, WEC, or its active ingredient bicycurum can reduce ethanol-induced liver damage. WEC and bicycurum both reduced plasma levels of aspartate amino transferase and alanine amino transferase, which are indicators of liver damage. Additionally, WEC and bicycurum increased hepatic levels of superoxide dismutase and glutathione, which are antioxidants, and decreased levels of thio-barbituric acid reactive substances, TNF protein, and Illinois 6M RNA, which are markers of inflammation. This suggests that WEC and bicycurum may be effective in reducing ethanol-induced liver damage by reducing oxidative stress and inflammation. This article was authored by Riasi Yukio, Yohei Higoshi, Yusuka Kawama, and others.