 Transitioning from pediatric to adult health care can be challenging for children with serious or chronic illnesses. This paper reviews existing literature on the topic and identifies key themes, such as patient, parent and health care provider perspectives, recommendations for transition care and barriers to effective transition. The authors propose pragmatic methods to enhance transition research to improve health and key outcomes. This article was authored by Sophie Lanskron, Gregory S. Sawicki, Catherine L. Hassell and others.