 The Enforce cohort is a national Danish prospective cohort of adults who received a severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 vaccine as part of the Danish national SARS-CoV-2 vaccination program. It was designed to investigate the long-term effectiveness, safety and durability of SARS-CoV-2 vaccines used in Denmark. A total of 6,943 adults scheduled to receive a SARS-CoV-2 vaccine in the Danish COVID-19 vaccination program were enrolled in the study prior to their first vaccination. Participants will be followed for a total of two years with five predetermined follow-up visits and additional visits in relation to any booster vaccination. Serology measurements are performed after each study visit. T-cell immunity is evaluated at each study visit for a subgroup of 699 participants. Safety information is collected from participants at visits following each vaccination. Data on hospital admissions, diagnoses, deaths and SARS-CoV. This article was authored by Henrik Nielsen, Isaac S Johansson, Leakey Larson, and others. We are article.tv, links in the description below.