 Pseudomonas originosa is an opportunistic pathogen that can infect any human tissue. It is highly adaptable due to its ability to maintain iron homeostasis through various mechanisms. Recent research has focused on developing strategies to combat this pathogen by targeting its iron homeostasis mechanisms. These include the use of iron chelators and memetics, disrupting cider for production and uptake, and using Trojan horse strategies to deliver antibiotics. Additionally, cider afford transporters are being explored as potential targets for vaccine development. This article was authored by Anna Sanchez Jiménez, Francisco J. Marcos Torres, and Maria A. Lamas.