 So, in this work we discovered and report a new genetic disease with mutations in a gene called NA-15. And in this work we found 32 unrelated families from throughout the world and we showed that they have mutations in this NA-15 gene that basically decrease the ability to modify other proteins, they're both their structure and function. And these individuals have intellectual disability as well as other physical anomalies like congenital heart defects and this complements really nicely our previous work with something called Ogden syndrome which had mutations in the same pathway inside the cell. And so the broader implications of the work are that these days we are able to identify multiple families like on the order of 30 or more families with mutations in the same gene and that really allows us to get at trying to understand the full spectrum of the expression of various different traits in multiple families. And then as we as a society begin to sequence millions of people we will be much more easily able to interpret mutations that we find in any one person based on the previous work that has been done in those more severe diseases.