 Hello everyone. We are going to talk about the practical aspects of soliqua today. So what is soliqua? It is a two medication in one. There is glard gene, which you will know from Lantus, which is the main ingredient, main insulin in Lantus, and there is lexacenotide, which is a gastrointestinal hormone known as Inquitins, which helps your body to make insulin secretion when you eat. So they developed this medication two in one to be able to help the blood sugar spikes and also passed in blood sugars that frequently happens, patients with diabetes. So how are we going to use this soliqua? Of course, you will get your dosing from your prescription and from your doctor, but practically this medication can stay in the refrigerator until the expiration date. Once you start using this pen, you can keep in the room temperature up to 28 days. Actually, once you open the pen and start using the first time, once you put the needle on it, you have 28 days to use it. It's either refrigerator or not. You have to use the pen within 28 days. Alright, so where can you inject? As you can see in this model, you can inject on your tie here, on your abdomen, spear in the umbilical area, the back of your arms, and the upper buttocks. Alright, so I'm going to consider this is your abdomen. I'm assuming this is nice and clean. If you did not shower for a while, you can make sure that you can clean it with a nice alcohol swap, but that's not absolutely necessary as we do not go too deep in your skin. So the first time you use a pen, this is true for any insulin pen, you need to make sure that you prime and first you have to put a needle. You remove the seal first and then you attach it to your needle and you can screw that on just like this and then you remove the cap from the pen needle and there will be another cap to remove. That's the inner cap and then as you can see there will be a very tiny needle there. You can already see the insulin coming out. You may actually not need to prime this, but most of the time you recommend priming at least with two units to start with. As you can see here when you push, there's a little drop coming out and if it doesn't you can do another two units until you see a real drop coming out and now you're primed. The priming is done because in this mechanism here there may be some air trapped and you do not want to inject less insulin or less medicine than you really need. So in this case, let's say your physician prescribed you 15 units. Now you will see you will see the non-unit 1 and 2 and then there will be a black thing in between. The reason they did that, there are actually doses around there, but the reason they did that, they want you to start at 15 units. They did the studies that way. So as a result, this medication starts at 15 units. Now they assume that you are on lontas or any other basal insulin before before you actually move to this medication. So as a result starting at 15 units is not necessarily a high dose. It is perfectly tolerable to any patients with type 2 diabetes. So in this case, let's say we are going to start at 15 units. Another reason actually for you not to start high is that it can give you some gastrointestinal upset due to the lexicinadide component. So it is a good idea to start low. Of course, if you are transitioning from another medication, you need to follow very specific instructions from your physician. Now in this case, I'm going to go ahead and give this 15 units of injection. Again, it's dialed up and nice and loaded and you have the pen needle right there. All you have to do is go directly 90 degree in and then push the plunger. And then once you push the plunger, you wait 5 to 10 seconds to make sure the complete delivery of the medication. And then you remove and you take the pen needle off and put it in a safe container for discarding later. In this case, since I have used this pen, this can stay in the room temperature. Again, this is saliqua, 2-in-1, instant aglargine and lexicinadide. Make sure you get specific instructions from your doctor before you use the medication. If you have any questions, don't hesitate to call your doctor and thank you for watching.