 Noble metal nanoparticles, MNPs, have been widely used in biosensors due to their unique properties such as high-surface area, catalytic activity, and biocompatibility. They can be used alone or in combination with other nanostructures to improve sensor performance. Recent developments in MNP-based biosensors have focused on improving sensitivity, selectivity, and stability. This article was authored by Malexad Hedi, Sahandi Zangabad Param, Mirshakari Hamed, and others.