 The study investigates the transcriptional architecture of cryptogenetic variation, CGV, in response to rapid temperature changes in kinohobditis elegans. The authors analyzed regulatory variation in gene expression across a heat stress and recovery response in a recombinant inbred population. They found that exposure to heat stress affected the transcription of 3,305 genes, while 942 were affected in recovering animals. These affected genes were mainly involved in metabolism and reproduction. The gene expression pattern in recovering animals resembled both the control and the heat stress treatment. The authors mapped EQTL using genetic variation in the population and detected 2,626 genes with an EQTL in the heat stress treatment, 1797 in the control and 1880 in the recovery. They found that a considerable fraction of trans EQTL, 40 to 57%, mapped to treatment-specific trans bands, while approximately 67% of the trans EQTL were only induced in a single treatment. The study illustrates the highly dynamic pattern of CGV across different environmental conditions and suggests that response-related trans regulatory EQTL play a significant role in determining CGV. This article was authored by Basten L. Snoke, Mark G. Sturkin, Role P. J. Bevers, and others. We are article.tv, links in the description below.