 This paper reviews the importance of monitoring antibiotic levels in different matrices and the need for sensitive and selective detection methods. It also examines the use of electro-analytical techniques which are more sensitive than traditional methods to detect antibiotics. Examples of nanoparticle modified electrodes that have been used successfully for the detection of a wide range of antibiotics are provided. This article was authored by Christina Sara Katzenu, Sophia Karastagiani and Stella Geroussi.