 Cardiorespiratory fitness is strongly linked to a reduced risk of developing type 2 diabetes. Genetic factors play a role in determining one's level of fitness and these genetic factors can be used to predict an individual's risk of developing type 2 diabetes. Additionally, certain proteins may act as mediators of this relationship, suggesting that increasing levels of physical activity could help reduce the risk of developing type 2 diabetes. This article was authored by Lina CAI, Thomas Gonzalez, Eleanor Wheeler, and others.