 Oral delivery is the most popular route of drug administration due to its convenience and ease of use. However, it also presents several challenges such as low bioavailability, poor solubility, and difficulty in controlling release kinetics. Recent advances in technology have allowed for the development of novel approaches to address these issues, including the use of nanotechnology, lipid-based carriers, and polymeric microspheres. These technologies have enabled the development of more effective oral drug delivery systems, leading to improved patient compliance and better clinical outcomes. This article was authored by Bamun Homayoon, Shih Uetting Lin, and Hyojik Choi.