 The study assesses the cost-effectiveness of introducing universal childhood rotavirus vaccination with Rotovac vaccine in Bangladesh's national expanded program of immunization, finding it highly cost-effective and would offer substantial future benefits for young population if vaccinated today. The cost per daily averted is approximately $740.27 from the health system perspective and $728.67 from societal perspective, which is very cost-effective using GDP threshold level according to World Health Organization definition. The results contribute to an evidence-based recommendation about the introduction of universal rotavirus vaccination in national EPI in Bangladesh. This article was authored by Abdul Razzaq Saka, Marifa Sultana, Rashid Al Alam Maheemid and others.