 This study investigated the surface modification of cellulose nanocrystals, CNCs, to create a biocompatible, stable, and hydrophilic substrate suitable for use as a coating agent to develop a dual-contrast composite material. The CNCs were prepared using acid hydrolysis, followed by PG slash NaOH treatment. The resulting particles had a high degree of colloidal stability, small hydrodynamic size, and good biocompatibility. Additionally, they could be used as a dual-contrast agent for magnetic resonance imaging, MRI, techniques, and other biomedical applications. This article was authored by Fathya Waba, Faisal Mohamed, Mohamed Idzat Idris, and others.