 Gastric cancer is a deadly cancer worldwide, with stomach cancer being the fifth most common neoplasm and third most deadly cancer in 2018, with an estimated 783,000 deaths. The incidence and mortality of gastric cancer are highly variable by region and dependent on diet and helicobacter pylori infection. While H. pylori infection has been decreased through prevention and treatment, it has contributed to an increase in cardiac gastric cancer. A better understanding of the etiology and risk factors of the disease can help approach H. pylori infection. Dietary modification, smoking cessation, exercise, and genetic testing hold promise in preventing and diagnosing gastric cancer. This article was authored by Prashant Rala and Adam Barsuk.