 UCSF is a remarkable place. I mean, we were at the beginning of the molecular biology revolution. With the launch of CTSI, I think our focus has been broadened. The clinical translational science institutes really pushing the boundaries for translational research, which is a big trend nationally. CTSI is a unique organization in that it addresses the research needs along every stage of the research trajectory. So starting from basic science on early translation, all the way to making an impact on community health. The bedside is the bench. And that's exactly, I think, where we need as an institution to go, and I think it's highly likely that we'll get there. The concern by the public was that they'd spent a lot of money on research, and they'd seen little health benefit from it. In the academic lab, it's an individual who's gathering the data. On a medical floor, in a hospital, it's a team of clinicians that help the patient to get better. And what CTSI is doing is bridging that gap, if you will, between the team and the individual, and bringing together multidisciplinary teams to ask the question, what obstacles confront us, and to think carefully about how to either jump over them or get around them, or define new ways, actually, of doing what we want to do. And how we've done that at UCSF is through a whole series of programs, some related to providing infrastructure to make it easier for researchers to get the job done. Things like support for planning of clinical trials, dealing with regulatory hurdles, quicker and more efficient funding mechanisms to carry out the planning grant that would be the beginning point of a larger study, consultation services, things that just never really existed before. Given the complexity of research today, many investigators just can't be successful without first grade training. So the UCSF CTSI provides a whole range of training, medical, nursing, pharmacy and dental students, broad training, as well as very focused training. So we have specific programs for people who are interested in bench-to-bedside research, and also people who are interested in translating what we already know into the clinic and into public health. We identify gaps and help bridge them. So we look for areas where UCSF needs to expand its services, its infrastructure, and then come up with really creative ways to meet those needs. One of the biggest gaps we saw was the lack of a coherent approach to recruit participants into trials and studies at UCSF. Recruitment of participants in the research is where many studies fail. Most of the studies we carry out require hundreds, thousands, often 10,000 people with each person having a million different variables. It's really the purpose of the CTSI to address these impediments. So CTSI came in and created the first-ever Participant Recruitment Service at UCSF. CTSI is also focused on the development of early-stage ideas and research concepts that can be translated into advancing health. We created a unique program called T1Catalyst that helps investigators at that stage understand exactly where their research is at, given all the steps that are necessary to bring it to market, and then matches them up with experts that are relevant to their research and helps them resolve issues early on on intellectual property and commercialization. We recognize that we're not a drug company. We're not a device company. We're not going to get this stuff done on our own in academia. And so in order to really improve health, we need to think about partnerships. And in that spirit, industry partners are very important to us, ranging from big or small pharma, biotechs, service partners. Community partners are really important because once you get therapies and interventions, we have to make sure that they actually make impact out of the world. We're a part of a large national consortium, and our goal there is to take the best models of our work and amplify those through a national reach. In addition, we're able to do better work at UCSF because we're taking the best of what the national consortium can provide and bring those solutions to bear. Everything that we learn, every process, every step that we make here locally is applicable abroad. Everything that we do that allows us to better understand how to bridge this gulf here is something that we can transport. Discovery is still very, very important. Just discovery for discovery's sake. We find a lot of things out that we didn't expect. It leads us in directions that we couldn't anticipate. But doing discovery in a way that gets us two improvements in health, that's what our charge is. We are actually bringing together the research from UCSF, connecting it to community partners, and asking, can we actually make measurable changes in health in the San Francisco Bay Area community? That is the ambition. We're very excited to see the dividends it will pay over the next five years.