 This paper examines the experiences of gay men and transgender women in Belo Horizonte, minus de Ray State, Brazil, who participated in the PREP-1519 study. The participants were interviewed and found to be motivated by the desire to take control of their own health and protect themselves against HIV. They also reported using PREP alongside condom use, either as an additional form of protection or as the primary method of protection. Additionally, the participants discussed how their gender performances and experiences with hormone therapy influenced their understanding of PREP. Finally, the participants families were found to have mixed reactions to the idea of PREP, with some questioning its preventive function while others accepted it as a voluntary choice. Overall, the participants' narratives suggest that PREP has become integrated into their lives and can be used to improve sexual freedom and overall well-being. This article was authored by Erica Dumont-Pena, Mateus Rodriguez Weston, Maria José Duarte and others.