 The study evaluated the feasibility of delivering an evidence-based mobile health, M Health, app with an embedded conversational agent to deliver cognitive behavioral therapy, CBT, to symptomatic adolescents presenting in primary care settings during the COVID-19 pandemic. The pilot randomized controlled trial, RCT, included 17 participants and demonstrated the feasibility, acceptability, usability, and safety of using a CBT-based chatbot for adolescents with moderate depressive symptoms in a network of PBRN-based primary care clinics. However, the study could not establish effectiveness, and future study inclusive of rural, socio-economically disadvantaged, and underrepresented communities is needed to establish generalizability of effectiveness and identify implementation-related adaptations needed to promote broader uptake in pediatric primary care. This article was authored by Ginger Nicol, Ruoyun Wang, Sharon Graham, and others.