 In the global burden of disease study conducted in 2010, depressive disorders were found to be a leading cause of burden worldwide. Major depression, MDD, accounted for 8.2% of total years lived with disability, wildese, while the stemia accounted for 1.4%. MDD was also found to be a significant contributor to the burden of suicide and ischemic heart disease, accounting for 16 million and 3.8 million dailies respectively.