 This research paper examines the structure and dynamics of a six-duplex DNA nanostructure in different environments. In simple solvents, the structure differs from what was expected based on the design, but when placed inside a lipid bilayer, the structure returns to its intended design. Additionally, the salt concentration affects the stability of the structure, which could have implications for future applications such as sensors or drug delivery systems. This article was authored by Katia Ahmed, Abid Javad, Conor Lanfair, and others.