 In this study, researchers examined the effects of liposomal berberine on liver damage caused by type 2 diabetes mellitus, T2DM. They found that liposomal berberine was able to restore liver tissue microarchitecture, reduce deatosis and liver function, and regulate lipid metabolism. Additionally, they discovered that liposomal berberine activates autophagy through the activation of LC3-2 and CLIN-1 proteins, as well as the AMPK-M2R pathway. Furthermore, liposomal berberine increases glucagon-like peptide-1, GLP-1, expression, which stimulates insulin production. This leads to a decrease in endoplasmic reticulum stress, which limits the CHOP, JNK expression, oxidative stress, and inflammation. Overall, these results suggest that liposomal berberine may be effective for treating liver damage caused by T2DM. This article was authored by Safa Aykater, Tagrid N. Almeina, Doa M. Abdel Fata, and others. We are article.tv, links in the description below.