 This study found that certain amino acids in a specific mitochondrial protein could lead to clogging of the protein import pathway, which caused impaired mitochondrial respiration, cytosolic proteostasis, and cell viability. Additionally, the study showed that these mutated proteins could cause neurodegenerative diseases and age-related muscle weakness in mice. This article was authored by Liam Peacoyne, Xiaowen Wang, Jiaosong, and others.