 Optic nerve disorders are a group of conditions characterized by the loss of retinal ganglion cells, RGCs, and subsequent degeneration of the optic nerve. These disorders have various causes including genetic mutations, trauma, and environmental factors such as oxidative stress. Oxidative stress is an imbalance between the production of reactive oxygen species, ROS, and the body's ability to neutralize them. It has been implicated in the pathogenesis of several optic nerve disorders, including glaucoma, labor's hereditary optic neuropathy, LHON, anterior ischemic optic neuropathy, AION, and optic neuritis, on. Preclinical studies suggest that antioxidant therapies may be beneficial for treating these disorders. This article was authored by Francesco Buenfilio, Elsa Wilma-Bohm, Norbert Pfeiffer, and others.