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Secondary necrosis of an aged neutrophil

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Published on Aug 10, 2009

Secondary necrosis is defined as necrosis that occurs after a cell has undergone apoptosis (cell suicide). In comparison to primary necrosis (see my other video), secondary necrosis is a lot slower process (this took place over approx. 250 seconds) and it appears that the membrane remains intact. However, tests with Fluo4 (calcium indicator - not shown here), show the neutrophil membrane to have ruptured as the membrane insoluble fluo4 leaks out. For further info contact me at the Neutrophil Signalling Group, School of Medicine, Cardiff University, Wales, UK. See http://medicine.cf.ac.uk/en/research/... for more about my work.

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