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Published on Feb 19, 2014
Table of Contents: 00:09 Lecture 2.6: Beating the Limits -- Droplet Evaporation 01:24 Outline 01:47 A 'Mendeleev Table' for bionsensors 02:41 Strategies to beat the diffusion limit 04:00 Biomimetics: Droplet on a leaf and coffee stain 06:33 Technology: Super-hydrophobic surfaces 08:57 Theory of droplet evaporation 13:17 Supersensitive droplet sensor 15:11 How to create a droplet: Basics 17:01 Derivation of Young's Equation 20:01 Corrugation improves hydrophobicity 21:33 Droplet evaporation enhances sensitivity 23:05 Geometry of diffusion & phase space of biosensors 23:39 Response time for various geometries 23:59 Conclusions
This course provides an in-depth analysis of the origin of the extra-ordinary sensitivity, fundamental limits, and operating principles of modern nanobiosensors. The primary focus is the physics of biomolecule detection in terms of three elementary concepts: response time, sensitivity, and selectivity. And, it potentiometric, amperometric, and cantilever-based mass sensors to illustrate the application of these concepts to specific sensor technologies.