 The paper examines the impact of psychiatric comorbidities, particularly depression, on the outcomes of tuberculosis, TB. It also explores how psychiatric comorbidities can lead to poor medication adherence among TB patients. Studies have shown that depression is highly prevalent among TB patients, and this has been linked to poor medication adherence. Additionally, other psychological reactions and disease perceptions have been identified as potential contributors to poor medication adherence. Overall, the paper suggests that better management of comorbid conditions, including depression, could improve medication adherence and serve as a framework for effective TB control. Further research is needed to determine the best ways to address these issues among TB patients. This article was offered by Argyro Pachi, Dinesios Bratis, Giorgio Smousis and others.