 Glutathione, GSH, has been found to play a crucial role in various physiological processes such as nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions, including gene expression, DNA, and protein synthesis, signal transduction, cell proliferation, apoptosis, nitroxidative stress modulation, autophagy, and viral infection. This article was authored by Katia Iacolano, Sara Ibaldeli, and Maria Rosa Isiriolo.