 Northwest Arkansas, particularly Benton and Washington counties, is one of the highest COVID-19 hotspots in the United States, U.S., with more than half of all reported cases in this area identifying as Latinx or Pacific Islander, even though these communities account for less than 20% of the overall population. The University of Arkansas for Medical Sciences, UAMS, leveraged their existing relationship with 18 key community partners. Partners collaboratively developed a COVID-19 response strategy to ensure coordinated effort for Latinx and Pacific Islander communities with four interrelated strategies, health education, testing, contact tracing, and supported quarantine case management. This article was authored by Pearl A. McElphish, Anna B. Cleak, Don E. Willis, and others.