 The use of dietary and metabolic therapies to treat various neurological diseases has been attempted, including epilepsy, headache, neurotrauma, Alzheimer's disease, Parkinson's disease, sleep disorders, brain cancer, autism, pain, and multiple sclerosis. The motivation for using these treatments stems from the lack of effectiveness of pharmacological therapies and the appeal of a more natural treatment. However, the spectrum of pathophysiological mechanisms underlying these diseases suggests that dietary interventions may not be effective universally. Nonetheless, it is possible that alterations in certain dietary constituents could affect the course and outcome of these brain disorders. The ketogenic diet, KD, has been shown to be effective against medically intractable epilepsy by normalizing aberrant energy metabolism. This concept suggests that many neurological conditions may be linked pathophysiologically to energy dysregulation, providing a common research and experimental therapeutics platform for influencing the course of several neurological diseases through dietary means. This article was authored by John Monroe and Carl E. Staffstrom. We are article.tv. Links in the description below.