 Enzamin is a natural product derived from the bark of the Chinese medicinal plant in Zafrotinensis. It has been shown to have beneficial effects on obesity-related metabolic disorders such as hyperglycemia, hyperlipidemia, and insulin resistance in obese Db, Db mice. Enzamin treatment reduced fasting plasma glucose, total cholesterol, and triglycerides, while maintaining normal body weight and body fat composition. Additionally, it improved insulin sensitivity and glucose tolerance, which suggests that Enzamin may be a promising therapeutic option for treating obesity-related metabolic disorders.