 This study investigates the effectiveness of percutaneous kyphoplasty, PKP, combined with solidronic acid, a cluster, in treating osteoporotic vertebral compression fractures, OVCF. The results show that one week after operation, both groups showed improvement in visual analogue scale, VAS, and Oswistry Disability Index, ODI, but the experimental group continued to improve, while the control group worsened rapidly one year after operation. Bone mineral density improved significantly six months and one year after operation in the experimental group, but bone metabolism decreased significantly. For patients in the control group suffered from OVCF again and three patients had fever symptoms during the follow-up period. Overall, the study suggests that PKP combined with a cluster is effective in treating and preventing OVCF. This article was authored by Bin Liu, Fushengan, UGE, and others.