 Silver nanoparticles have antiviral activity against HIV-1 at non-cytotoxic concentrations, and they exert this activity by binding to GP-120 and inhibiting viral entry and pieced-entry stages of the life cycle, making them a broad-spectrum agent that could be used preventively against circulating HIV-1 strains. This article was authored by Rudry Gispedila-Christina, Ixtapantaran Liliana, Ayala Nenius Nildavee and others.