 Nanoparticles, in-piece, have been widely used in various applications such as biology, medicine, and electronics. However, their use has been limited due to the difficulty of maintaining them in solution in high ionic strength environments. To address this issue, several strategies have been developed to stabilize in-piece in these conditions. These include the addition of surfactants or polymers, the use of organic solvents, and the application of antifouling agents. Additionally, methods have been developed to prevent the adsorption of proteins onto the in-piece, thus preserving their functionality. This article was authored by Luca Garini, Ramon A. Alvarez-Puebla, and Nicholas Pozosparis.